The term syndemic refers to the synergistic interaction between multiple health threats, often exacerbated by societal circumstances, which together contribute to an excess burden of disease. A primary example of this phenomenon is the syndemic of viral hepatitis, STIs, substance use disorders, and mental health conditions.
ASTHO supports state and territorial health departments in their efforts to address syndemic-related infections. In collaboration with CDC and other key partners, ASTHO is engaged in activities to raise awareness about syndemic issues, establish and strengthen cross-sector partnerships, and provide capacity-building assistance to jurisdictions in integrating efforts across syndemic conditions.
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Multi-Strategy Approaches to Viral Hepatitis Elimination
This suite of microlearning tools, housed in ASTHO's e-Learning Center, outlines strategies and resources to address hepatitis among diverse populations and within various health care settings.
Innovative STD Prevention and Treatment Strategies
These microlearnings, featuring the work of the Strengthening STD Prevention and Control for Health Departments grantees, translate successful interventions into accessible and easily understood tools.
State Strategies for Advancing Viral Hepatitis Elimination
This report synthesizes key actions and proven strategies for public health leaders to consider as they approach hepatitis elimination planning.
Latest Syndemic-Related Infections Resources

Approaching Public Health Issues Among People Who Use Drugs Through a Syndemic Lens
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Boundary Spanning Leadership Model Strengthens Oklahoma Harm Reduction Programs
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State Legislative Activity Supports Federal Evidence-Based HIV Prevention Initiative
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Forward Focus: The Urgent Need to Address Rising Cases of Viral Hepatitis
Learn MoreCollaborations
ASTHO and NASTAD have a longstanding partnership to collaboratively address HIV. In support of the national Ending the HIV Epidemic Initiative (EHE), ASTHO has partnered with NASTAD to provide technical assistance and build capacity of state HIV directors and state health agency across a variety of topics to address health system transformation.