ASTHO developed evidence-based public health case studies of six states to demonstrate a wide range of evidence-based strategies for addressing complex, public health problems. While their approaches and objectives vary, the six states use a common framework to develop evidence-based interventions that respond to local needs. In addition, the states rely on tools such as recommendations contained in The Guide to Community Preventive Services (The Community Guide) to address a wide range of public health challenges, including obesity, pregnancy-related depression and childhood immunizations.